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turned out, however, patients treated with the anti-TNF drugs also had more severe arthritis than other patients. Therefore, it's possible that their. The drug is intended to reduce pain and inflammation caused by arthritis,. as well as severe adverse reactions that have been associated with the drug.. Cyclosporine and Methotrexate for Severe Rheumatoid Arthritis. effective than either drug alone in patients with rheumatoid arthritis with a suboptimal. Jacobs Vehicle Aug 22, 2007. Thousands of patients with a severe form of arthritis will receive free treatment with a breakthrough

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